November 4th, 2015
Addyi – also popularly referred to as female Viagra have recently been approved by FDA for use in women with hypoactive sexual desire syndrome. The active compound in Addyi is flibanserin, which is believed to exert its action by improving the biochemical balance in the females to strength libido naturally while reducing the distress associated with sexual encounters by more than 29%.
Hypoactive sexual desire disorder is fairly common in females and according to rough estimates, approximately one out of ten females suffer from HSDD; which is classically defined as “an extremely low urge to engage in sexual encounter despite being in a normal, healthy and loving relationship”. According to another study, more than 5 to 25% females experience low libido and sexual distress that can significantly affect the quality of relationships (1).
Traditionally, Viagra in males exert its action by increasing the perfusion of blood to the sexual organs (or penis). The female Viagra (or Addyi) on the contrary, exerts its action by restoring the natural balance of neurotransmitters in the brain.
It has been reported that the primary pathophysiology of HSDD revolves around poor rhythm or balance between classic neurotransmitters in the brain; such as serotonin, dopamine and norepinephrine. Addyi, once consumed can help in restoration of biochemical balance to promote libido and sexual desires in the females. The ideal candidates for this drug are; pre-menopausal women who are in happy relationships and wants to engage in sexual intercourse but suffers from unexplained poor libido or low sexual desires.
Based on the clinical trials conducted in over 11,000 females with a known history of HSDD for a period of at least 4 years, it was concluded that:
It is imperative to mention that based on the findings of SNOWDROP Trial (3), it can be safely concluded that the drug flibanserin (or Addyi) is safe and effective even in post-menopausal females if consumed in a dose of 100 mg/ day. If you are experiencing low libido due to menopause, make sure to speak to your primary care provider for Addyi prescription.
Some cautions and concerns that should be maintained with Addyi are:
A lot of people argue if females actually need Viagra like drug instead of psychotherapy. The answer is pretty clear. Women who suffer from hypoactive sexual desire disorder have a biochemical disturbance. In other words, psychotherapy is only helpful in cases when sexual dysfunction is due to a marital issue, psychological dysfunction or other social/ personal or cultural issues and may have no effect in women who are suffering from true HSDD.
It is very important to identify the actual cause of sexual dysfunction before opting for any treatment.
1. Jin, J. (2015). Flibanserin for Treating Low Sexual Desire in Women. JAMA, 314(12), 1312-1312.
2. Dhanuka, I., & Simon, J. A. (2015). Flibanserin for the treatment of hypoactive sexual desire disorder in premenopausal women. Expert opinion on pharmacotherapy, 1-7.
3. Simon, J. A., Kingsberg, S. A., Shumel, B., Hanes, V., Garcia Jr, M., & Sand, M. (2014). Efficacy and safety of flibanserin in postmenopausal women with hypoactive sexual desire disorder: results of the SNOWDROP trial. Menopause, 21(6), 633-640.
Schedule your private consultation with Dr. Elist
Through experience, empathy, and patient empowerment, Dr. Elist offers a comprehensive and detail-oriented treatment plan for every patient. Schedule your consultation to discuss treatments for men in Los Angeles with premier surgeon Dr. James Elist, and begin your journey confident that your best results are just ahead of you.